Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor
نویسندگان
چکیده
منابع مشابه
Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor.
The aryl hydrocarbon receptor (AhR) has become increasingly recognized for its role in the differentiation and activity of immune cell subsets; however, its role in regulating the activity of natural killer (NK) cells has not been described. Here, we show that AhR expression is induced in murine NK cells upon cytokine stimulation. We show that in the absence of AhR, NK cells have reduced cytoly...
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Natural killer (NK) cells are a heterogenous subpopulation of peripheral blood lymphocytes (PBL) that have the ability to kill various tumors and tumor cell lines in the absence of prior sensitization. These cells have generated considerable interest and have been implicated in natural resistance to tumors,'-5 resistance to viral infection:-7 transplantation rejection,'** and immunoregulation o...
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A tissue-resident population of natural killer cells (NK cells) in the liver has recently been described to have the unique capacity to confer immunological memory in the form of hapten-specific contact hypersensitivity independent of T and B cells. Factors regulating the development and maintenance of these liver-resident NK cells are poorly understood. The aryl hydrocarbon receptor (AhR) is a...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1302856110